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Top Bio Pharmaceutical Companies in USA List by Market Cap as of August 2026

Top Bio Pharmaceutical Companies in USA List by Market Cap as of August 2026. Biggest and Top Bio Pharmaceutical Companies in USA Companies by Market Cap. Largest Top Bio Pharmaceutical Companies in USA List by Market Cap as of August 2026.
Metatag Title
Top Bio Pharmaceutical Companies in USA
Metatag Abstract
Top Bio Pharmaceutical Companies in USA, Biggest Bio Pharmaceutical Companies in USA, Largest Bio Pharmaceutical Companies in USA.
  1. Amgen

    World Rank (Aug-2026)
    83
    Market Cap (Aug-2026)
    224.092 Billion USD
    World Rank (Jan-05-2024)
    73
    Market Cap (Jan-05-2024)
    162.250 Billion USD
    World Rank (Jul-30-2023)
    105
    Market Cap (Jul-30-2023)
    126.300 Billion USD
    World Rank (Dec-25-2022)
    80
    Market Cap (Dec-25-2022)
    140.820 Billion USD
    World Rank (Jan-07-2022)
    113
    Market Cap (Jan-07-2022)
    128.03 Billion USD
    Annual Revenue in USD
    36,751 Million USD
    Annual Operating Income in USD
    9,080 Million USD
    Annual Net Income in USD
    7,711 Million USD
    Annual Results for Period Ending
    Dec-2025 ending year
    Headquarters Country
    Company Profile

    Amgen main mission is to serve patients. Amgen is leader in Biotechnology industry, research and making Biotechnology Products. Company has over 25,200 employees as on 2022. Headquarters is in California, USA.

    Amgen Prevents Infections in Cancer Patients Program to Launch Innovative Tools to Improve Patient-Provider Conversations

    Amgen is dedicated to the fight against heart disease and has now launched Breakaway from Heart Disease™. The collective goal of this national campaign is to help make America’s heart health a priority.

    Facts About Company

    As on 2022, Amgen has 25,200 employees.

    Amgen annual revenue generated for period ending Dec-2022 was 26,323 million USD.

    Amgen annual net income generated for period ending Dec-2022 was 6,552 million USD.

    Amgen annual revenue generated for period ending Dec-2021 was 25,979 million USD.

    Split of Annual Revenue by business segment for period ending Dec-2021:

  2. Gilead Sciences

    World Rank (Aug-2026)
    127
    Market Cap (Aug-2026)
    171.560 Billion USD
    World Rank (Jan-05-2024)
    133
    Market Cap (Jan-05-2024)
    105.265 Billion USD
    World Rank (Jul-30-2023)
    154
    Market Cap (Jul-30-2023)
    95.871 Billion USD
    World Rank (Dec-25-2022)
    120
    Market Cap (Dec-25-2022)
    106.300 Billion USD
    World Rank (Jan-07-2022)
    180
    Market Cap (Jan-07-2022)
    89.39 Billion USD
    Annual Revenue in USD
    29,443 Million USD
    Annual Operating Income in USD
    10,022 Million USD
    Annual Net Income in USD
    8,510 Million USD
    Annual Results for Period Ending
    Dec-2025 ending year
    Headquarters Country
    Stock Category
    Company Profile

    GILEAD SCIENCES INC is world’s largest bio-pharmaceutical companies. As on Dec-2021, Gilead Sciences had 14,400 employees across six continents and headquarters is in USA,

    As on 2022, GILEAD SCIENCES INC has 17,000 employees.

    GILEAD SCIENCES INC annual revenue generated for period ending Dec-2022 was 27,281 million USD.

    GILEAD SCIENCES INC annual net loss generated for period ending Dec-2022 was 4,592 million USD.

  3. Bristol-Myers Squibb Company

    World Rank (Aug-2026)
    177
    Market Cap (Aug-2026)
    130.386 Billion USD
    World Rank (Jan-05-2024)
    130
    Market Cap (Jan-05-2024)
    106.418 Billion USD
    World Rank (Jul-30-2023)
    100
    Market Cap (Jul-30-2023)
    129.010 Billion USD
    World Rank (Dec-25-2022)
    66
    Market Cap (Dec-25-2022)
    154.980 Billion USD
    World Rank (Jan-07-2022)
    96
    Market Cap (Jan-07-2022)
    139.46 Billion USD
    Annual Revenue in USD
    48,194 Million USD
    Annual Operating Income in USD
    10,002 Million USD
    Annual Net Income in USD
    7,055 Million USD
    Annual Results for Period Ending
    Dec-2025 ending year
    Headquarters Country
    Stock Category
    Company Profile

    Bristol-Myers Squibb is USA based healthcare and pharmaceutical multi-national company.

    BMS is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

    Company has over 32,200 employees as on 2021. Headquarters is in USA.

    BMS discover, develop and deliver innovative medicines that help patients prevail over serious diseases

    BMS be the biopharma company that transforms patients' lives through science.

    Facts About Company

    As on 2022, Bristol-Myers Squibb has 34,300 employees.

    Bristol-Myers Squibb annual revenue generated for period ending Dec-2022 was 46,159 million USD.

    Bristol-Myers Squibb annual net income generated for period ending Dec-2022 was 6,327 million USD.

    As on 2021, BMS had strong financial results with total revenues growing 9 percent year-over-year to $46.4 billion.

    Bristol-Myers Squibb annual revenue generated for period ending Dec-2021 was 46,385 million USD.

  4. Vertex Pharmaceuticals

    World Rank (Aug-2026)
    183
    Market Cap (Aug-2026)
    128.188 Billion USD
    World Rank (Jan-05-2024)
    129
    Market Cap (Jan-05-2024)
    107.235 Billion USD
    World Rank (Jul-30-2023)
    161
    Market Cap (Jul-30-2023)
    91.186 Billion USD
    World Rank (Dec-25-2022)
    182
    Market Cap (Dec-25-2022)
    74.361 Billion USD
    World Rank (Jan-07-2022)
    323
    Market Cap (Jan-07-2022)
    56.41 Billion USD
    Annual Revenue in USD
    12,001 Million USD
    Annual Operating Income in USD
    4,173 Million USD
    Annual Net Income in USD
    3,953 Million USD
    Annual Results for Period Ending
    Dec-2025 ending year
    Headquarters Country
    Stock Category
    Company Profile

    VERTEX PHARMACEUTICALS is USA Based Bio-Technology, Bio-Pharmaceutical and Healthcare Company.It have research and development sites, manufacturing facilities and offices around the world. The company locations are North America, Europe, Australia, South America.

    As on 2022, VERTEX PHARMACEUTICALS has 4,500 employees.

    VERTEX PHARMACEUTICALS annual revenue generated for period ending Dec-2022 was 8,930 million USD.

  5. Regeneron Pharmaceuticals

    World Rank (Aug-2026)
    313
    Market Cap (Aug-2026)
    82.722 Billion USD
    World Rank (Jan-05-2024)
    144
    Market Cap (Jan-05-2024)
    100.011 Billion USD
    World Rank (Jul-30-2023)
    174
    Market Cap (Jul-30-2023)
    81.855 Billion USD
    World Rank (Dec-25-2022)
    166
    Market Cap (Dec-25-2022)
    79.143 Billion USD
    World Rank (Jan-07-2022)
    279
    Market Cap (Jan-07-2022)
    64.93 Billion USD
    Annual Revenue in USD
    14,343 Million USD
    Annual Operating Income in USD
    3,578 Million USD
    Annual Net Income in USD
    4,505 Million USD
    Annual Results for Period Ending
    Dec-2025 ending year
    Headquarters Country
    Stock Category
    Company Profile

    REGENERON PHARMACEUTICALS is Bio-Pharmaceutical company with headquarters is in New York, USA.

    As on 2022, REGENERON PHARMACEUTICALS has 11,851 employees.

    Facts About Company

    REGENERON PHARMACEUTICALS annual revenue generated for period ending Dec-2022 was 12,172 million USD.

    REGENERON PHARMACEUTICALS annual net income generated for period ending Dec-2022 was 4,338 million USD.

    As on 2022, they had 11,851 employees. They had 7 FDA approved medicines.

  6. Alnylam Pharmaceuticals

    World Rank (Aug-2026)
    855
    Market Cap (Aug-2026)
    30.595 Billion USD
    World Rank (Jan-05-2024)
    763
    Market Cap (Jan-05-2024)
    24.134 Billion USD
    World Rank (Jul-30-2023)
    762
    Market Cap (Jul-30-2023)
    24.817 Billion USD
    World Rank (Dec-25-2022)
    578
    Market Cap (Dec-25-2022)
    29.268 Billion USD
    World Rank (Jan-07-2022)
    1,156
    Market Cap (Jan-07-2022)
    17.72 Billion USD
    Annual Revenue in USD
    3,714 Million USD
    Annual Operating Income in USD
    502 Million USD
    Annual Net Income in USD
    314 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    Stock Category
    Company Profile

    ALNYLAM PHARMACEUTICALS is Biopharmaceutical company with headquarters is in Massachusetts, USA.ALNYLAM leaders from the biopharmaceutical industry, bringing together their experiences of drug discovery, drug development, and commercialization.Alnylam has led the translation of RNAi (RNA interference) from Nobel Prize-winning discovery into an innovative, entirely new class of medicines.

  7. Moderna

    World Rank (Aug-2026)
    1,016
    Market Cap (Aug-2026)
    25.280 Billion USD
    World Rank (Jan-05-2024)
    436
    Market Cap (Jan-05-2024)
    41.430 Billion USD
    World Rank (Jul-30-2023)
    397
    Market Cap (Jul-30-2023)
    45.234 Billion USD
    World Rank (Dec-25-2022)
    174
    Market Cap (Dec-25-2022)
    76.483 Billion USD
    World Rank (Jan-07-2022)
    188
    Market Cap (Jan-07-2022)
    86.71 Billion USD
    Annual Revenue in USD
    1,944 Million USD
    Annual Operating Income in USD
    -3,074 Million USD
    Annual Net Income in USD
    -2,822 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    Stock Category
    Company Profile

    Moderna is Biotechnology sector company with headquarters is in Massachusetts, USA. It has done good work on Covid-19 vaccine.

    As on 2022, Moderna has 3,900 employees.

    Moderna annual revenue generated for period ending Dec-2022 was 18.87 billion USD.

    Moderna annual net income generated for period ending Dec-2022 was 8.36 billion USD.

    Moderna annual revenue generated for period ending Dec-2021 was 16,471 million USD.

  8. Incyte Corporation

    World Rank (Aug-2026)
    1,044
    Market Cap (Aug-2026)
    24.356 Billion USD
    World Rank (Jan-05-2024)
    1,185
    Market Cap (Jan-05-2024)
    14.923 Billion USD
    World Rank (Jul-30-2023)
    1,265
    Market Cap (Jul-30-2023)
    14.075 Billion USD
    World Rank (Dec-25-2022)
    918
    Market Cap (Dec-25-2022)
    18.101 Billion USD
    World Rank (Jan-07-2022)
    1,253
    Market Cap (Jan-07-2022)
    16.17 Billion USD
    Annual Revenue in USD
    5,141 Million USD
    Annual Operating Income in USD
    1,515 Million USD
    Annual Net Income in USD
    1,287 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    Stock Category
    Company Profile

    Incyte Corporation is a Bio-Pharmaceutical company with headquarters is in Delaware, USA.

    As on 2021, Incyte Corporation has 2,094 employees, 989 are in research and development, 187 in medical affairs, 638 in sales and marketing and 280 in operations support, finance and administrative positions.

    As on 2022, Incyte Corporation has 2,324 employees.

    Incyte Corporation annual revenue generated for period ending Dec-2022 was 3,394 million USD.

  9. Guardant Health

    World Rank (Aug-2026)
    1,190
    Market Cap (Aug-2026)
    21.097 Billion USD
    World Rank (Jan-05-2024)
    4,291
    Market Cap (Jan-05-2024)
    3.083 Billion USD
    World Rank (Jul-30-2023)
    3,217
    Market Cap (Jul-30-2023)
    4.547 Billion USD
    World Rank (Dec-25-2022)
    4,241
    Market Cap (Dec-25-2022)
    2.858 Billion USD
    World Rank (Jan-07-2022)
    2,054
    Market Cap (Jan-07-2022)
    8.93 Billion USD
    Annual Revenue in USD
    982 Million USD
    Annual Operating Income in USD
    -437 Million USD
    Annual Net Income in USD
    -416 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    Company Profile

    GUARDANT HEALTH is Healthcare sector company related to research related to Cancer treatment. Headquarters is in California, USA.

  10. Neurocrine Biosciences

    World Rank (Aug-2026)
    1,534
    Market Cap (Aug-2026)
    15.524 Billion USD
    World Rank (Jan-05-2024)
    1,326
    Market Cap (Jan-05-2024)
    13.124 Billion USD
    World Rank (Jul-30-2023)
    1,672
    Market Cap (Jul-30-2023)
    10.026 Billion USD
    World Rank (Dec-25-2022)
    1,362
    Market Cap (Dec-25-2022)
    11.566 Billion USD
    World Rank (Jan-07-2022)
    2,475
    Market Cap (Jan-07-2022)
    7.15 Billion USD
    Annual Revenue in USD
    2,861 Million USD
    Annual Operating Income in USD
    619 Million USD
    Annual Net Income in USD
    479 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    Company Profile

    Neurocrine Biosciences is a Neuroscience Focused and Biopharmaceutical company. It is discovering and developing life-changing treatments for people with serious, challenging, under addressed neurological, endocrine and psychiatric disorders. The headquarters is in USA.

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