Top Pharmaceutical Companies in USA List by Market Cap as of August 2026

Top Pharmaceutical Companies in USA List by Market Cap as of August 2026. Biggest and Top Pharmaceutical Companies in USA Companies by Market Cap. Largest Top Pharmaceutical Companies in USA List by Market Cap as of August 2026.
Top Pharmaceutical Companies in USA
Top Pharmaceutical Companies in USA, Biggest Pharmaceutical Companies in USA, Largest Pharmaceutical Companies in USA.

  1. Eidos Therapeutics

    World Rank (Aug-2026)
    2,624
    World Rank (Jan-05-2024)
    2,624
    World Rank (Jul-30-2023)
    2,624
    World Rank (Dec-25-2022)
    2,624
    World Rank (Jan-07-2022)
    2,624
    Annual Revenue in USD
    27 Million USD
    Annual Operating Income in USD
    -40 Million USD
    Annual Net Income in USD
    -38 Million USD
    Annual Results for Period Ending
    For year ending December-2019
    Headquarters Country
    USA
    Company Profile

    Eidos Therapeutics is a Biopharmaceutical company with headquarters is in California, USA.

    Eidos Therapeutics was acquired by BridgeBio Pharma Inc in 2021.

     

    Company Website
    EIDOS THERAPEUTICS INC

  2. Arena Pharmaceuticals

    World Rank (Aug-2026)
    2,949
    World Rank (Jan-05-2024)
    2,949
    World Rank (Jul-30-2023)
    2,949
    World Rank (Dec-25-2022)
    2,949
    World Rank (Jan-07-2022)
    2,949
    Market Cap (Jan-07-2022)
    5.74 Billion USD
    Annual Revenue in USD
    0 Million USD
    Annual Operating Income in USD
    -624 Million USD
    Annual Net Income in USD
    -616 Million USD
    Annual Results for Period Ending
    For year ending December-2021
    Headquarters Country
    USA
    Company Profile

    Bio-pharmaceutical company with headquarters is in California, USA.

    Company Website
    ARENA PHARMACEUTICALS INC
    Wikipedia
    Wikipedia

  3. Amneal Pharmaceuticals

    World Rank (Aug-2026)
    3,076
    Market Cap (Aug-2026)
    6.322 Billion USD
    World Rank (Jan-05-2024)
    6,045
    Market Cap (Jan-05-2024)
    1.809 Billion USD
    World Rank (Jul-30-2023)
    8,910
    Market Cap (Jul-30-2023)
    0.965 Billion USD
    World Rank (Dec-25-2022)
    15,083
    Market Cap (Dec-25-2022)
    0.333 Billion USD
    World Rank (Jan-07-2022)
    11,500
    Market Cap (Jan-07-2022)
    0.69 Billion USD
    Annual Revenue in USD
    3,019 Million USD
    Annual Operating Income in USD
    394 Million USD
    Annual Net Income in USD
    72 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    USA
    Yahoo @ NYSE
    Company Profile
    Amneal Pharmaceuticals is an Integrated Specialty Pharmaceutical company. It is powered by a robust U.S. generics business and a growing branded business and focused on delivering outcomes that meet important medical needs, make quality medicines more accessible and more affordable and provide solutions for tomorrows health challenges. The headquarters is in USA.
    Company Website
    AMNEAL PHARMACEUTICALS INC

  4. Ligand Pharmaceuticals

    World Rank (Aug-2026)
    3,242
    Market Cap (Aug-2026)
    5.873 Billion USD
    World Rank (Jan-05-2024)
    7,621
    Market Cap (Jan-05-2024)
    1.227 Billion USD
    World Rank (Jul-30-2023)
    7,940
    Market Cap (Jul-30-2023)
    1.175 Billion USD
    World Rank (Dec-25-2022)
    5,769
    Market Cap (Dec-25-2022)
    1.822 Billion USD
    World Rank (Jan-07-2022)
    5,576
    Market Cap (Jan-07-2022)
    2.42 Billion USD
    Annual Revenue in USD
    268 Million USD
    Annual Operating Income in USD
    41 Million USD
    Annual Net Income in USD
    124 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    USA
    Yahoo @ Nasdaq
    Company Profile
    Ligand Pharmaceuticals is a Biopharmaceutical company focused on developing or acquiring technologies that help pharmaceutical companies discover and develop medicines. It is providing a diversified portfolio of biotech and pharmaceutical product revenue streams that are supported by an efficient and low corporate cost structure. The headquarters is in USA.
    Company Website
    LIGAND PHARMACEUTICALS INCORPORATED

  5. ACADIA Pharmaceuticals

    World Rank (Aug-2026)
    3,702
    Market Cap (Aug-2026)
    4.866 Billion USD
    World Rank (Jan-05-2024)
    2,957
    Market Cap (Jan-05-2024)
    4.917 Billion USD
    World Rank (Jul-30-2023)
    3,125
    Market Cap (Jul-30-2023)
    4.723 Billion USD
    World Rank (Dec-25-2022)
    4,658
    Market Cap (Dec-25-2022)
    2.505 Billion USD
    World Rank (Jan-07-2022)
    4,217
    Market Cap (Jan-07-2022)
    3.63 Billion USD
    Annual Revenue in USD
    1,072 Million USD
    Annual Operating Income in USD
    105 Million USD
    Annual Net Income in USD
    391 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    USA
    Yahoo @ Nasdaq
    Company Profile

    Acadia Pharmaceuticals is a Healthcare and Pharmaceutical company. The company is of food and drug administration for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. Around 8 million people in the United States are living with dementia and studies suggest that approximately 30% of people with dementia, 2.4 million people, experience dementia-related hallucinations and delusion. The headquarters is in USA.

    Company Website
    ACADIA PHARMACEUTICALS INC
    Wikipedia
    Wikipedia

  6. Supernus Pharmaceuticals

    World Rank (Aug-2026)
    5,237
    Market Cap (Aug-2026)
    2.806 Billion USD
    World Rank (Jan-05-2024)
    6,703
    Market Cap (Jan-05-2024)
    1.522 Billion USD
    World Rank (Jul-30-2023)
    6,453
    Market Cap (Jul-30-2023)
    1.657 Billion USD
    World Rank (Dec-25-2022)
    5,403
    Market Cap (Dec-25-2022)
    2.026 Billion USD
    World Rank (Jan-07-2022)
    7,241
    Market Cap (Jan-07-2022)
    1.58 Billion USD
    Annual Revenue in USD
    719 Million USD
    Annual Operating Income in USD
    -62 Million USD
    Annual Net Income in USD
    -39 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    USA
    Yahoo @ Frankfurt
    Company Profile
    Supernus Pharmaceuticals is a pharmaceutical company focused on the development and commercialization of products for the treatment of central nervous system diseases. The company annual revenue is 392.8 million USD and 464 employees as on 2019. The headquarters is in USA.
    Company Website
    SUPERNUS PHARMACEUTICALS INC

  7. Momenta Pharmaceuticals

    World Rank (Aug-2026)
    5,297
    World Rank (Jan-05-2024)
    5,297
    World Rank (Jul-30-2023)
    5,297
    World Rank (Dec-25-2022)
    5,297
    World Rank (Jan-07-2022)
    5,297
    Annual Revenue in USD
    24 Million USD
    Annual Operating Income in USD
    -298 Million USD
    Annual Net Income in USD
    -290 Million USD
    Annual Results for Period Ending
    For year ending December-2019
    Headquarters Country
    USA
    Company Profile

    Momenta Pharmaceuticals is a Biotechnology company. The headquarters is in USA.

    Johnson & Johnson acquired Momenta Pharmaceuticals as on Oct-2020 for 6.5 Billion USD.

    Facts About Company

    Johnson & Johnson acquired Momenta Pharmaceuticals as on Oct-2020 for 6.5 Billion USD

    Company Website
    MOMENTA PHARMACEUTICALS INC

  8. Portola Pharmaceuticals

    World Rank (Aug-2026)
    5,432
    World Rank (Jan-05-2024)
    5,432
    World Rank (Jul-30-2023)
    5,432
    World Rank (Dec-25-2022)
    5,432
    World Rank (Jan-07-2022)
    5,432
    Annual Revenue in USD
    117 Million USD
    Annual Operating Income in USD
    -271 Million USD
    Annual Net Income in USD
    -291 Million USD
    Annual Results for Period Ending
    For year ending December-2019
    Headquarters Country
    USA
    Company Profile

    Portola Pharmaceuticals is a Biotechnology company. It is having more than 380 employees and has offices around the globe and serves patients in more than 50 countries. The company has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome (aHUS) as well as the first and only approved complement inhibitor to treat anti-acetylcholine receptor (AchR) antibody-positive generalized myasthenia gravis (gMG) and neuromyelitis optica spectrum disorder.

  9. Ultragenyx Pharmaceutical

    World Rank (Aug-2026)
    5,466
    Market Cap (Aug-2026)
    2.612 Billion USD
    World Rank (Jan-05-2024)
    3,549
    Market Cap (Jan-05-2024)
    3.941 Billion USD
    World Rank (Jul-30-2023)
    4,303
    Market Cap (Jul-30-2023)
    3.053 Billion USD
    World Rank (Dec-25-2022)
    4,035
    Market Cap (Dec-25-2022)
    3.051 Billion USD
    World Rank (Jan-07-2022)
    3,267
    Market Cap (Jan-07-2022)
    5.03 Billion USD
    Annual Revenue in USD
    673 Million USD
    Annual Operating Income in USD
    -535 Million USD
    Annual Net Income in USD
    -575 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    USA
    Yahoo @ Nasdaq
    Company Profile

    Ultragenyx Pharmaceutical is a Clinical Stage Biopharmaceutical company. It committed to bringing to patients novel products for the treatment of rare and ultra rare diseases with a focus on serious debilitating genetic diseases. The company portfolio of approved therapies and product candidates aimed at addressing diseases with high unmet medical need and clear biology for which there are no approved therapies. The headquarters is in USA.

    Company Website
    ULTRAGENYX PHARMACEUTICAL INC

  10. Nektar Therapeutics

    World Rank (Aug-2026)
    5,639
    Market Cap (Aug-2026)
    2.467 Billion USD
    World Rank (Jan-05-2024)
    21,027
    Market Cap (Jan-05-2024)
    0.108 Billion USD
    World Rank (Jul-30-2023)
    21,502
    Market Cap (Jul-30-2023)
    0.103 Billion USD
    World Rank (Dec-25-2022)
    13,797
    Market Cap (Dec-25-2022)
    0.404 Billion USD
    World Rank (Jan-07-2022)
    5,673
    Market Cap (Jan-07-2022)
    2.34 Billion USD
    Annual Revenue in USD
    55 Million USD
    Annual Operating Income in USD
    -140 Million USD
    Annual Net Income in USD
    -164 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    USA
    Yahoo @ Nasdaq
    Company Profile
    Nektar Therapeutics is a research based development stage Biopharmaceutical company. It R&D pipeline of new investigational drugs includes treatments for cancer and auto immune disease and leverage Nektar's proprietary and proven chemistry platform in the discovery and design of new drug candidates. The headquarters is in USA.
    Company Website
    NEKTAR THERAPEUTICS
    Wikipedia
    Wikipedia

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