Top Pharmaceutical Companies in USA List by Market Cap as of August 2026

Top Pharmaceutical Companies in USA List by Market Cap as of August 2026. Biggest and Top Pharmaceutical Companies in USA Companies by Market Cap. Largest Top Pharmaceutical Companies in USA List by Market Cap as of August 2026.
Top Pharmaceutical Companies in USA
Top Pharmaceutical Companies in USA, Biggest Pharmaceutical Companies in USA, Largest Pharmaceutical Companies in USA.

  1. Biohaven Pharmaceutical Holding Company

    World Rank (Aug-2026)
    6,000
    Market Cap (Aug-2026)
    2.211 Billion USD
    World Rank (Jan-05-2024)
    3,972
    Market Cap (Jan-05-2024)
    3.399 Billion USD
    World Rank (Jul-30-2023)
    7,470
    Market Cap (Jul-30-2023)
    1.300 Billion USD
    World Rank (Dec-25-2022)
    8,706
    Market Cap (Dec-25-2022)
    0.934 Billion USD
    World Rank (Jan-07-2022)
    2,147
    Market Cap (Jan-07-2022)
    8.44 Billion USD
    Annual Revenue in USD
    463 Million USD
    Annual Operating Income in USD
    -704 Million USD
    Annual Net Income in USD
    -847 Million USD
    Annual Results for Period Ending
    For year ending December-2021
    Headquarters Country
    USA
    Yahoo @ NYSE
    Company Profile

    Biohaven Pharmaceutical Holding Company is a Clinical Stage Biopharmaceutical company. It portfolio is comprised of innovative, late stage product candidates targeting neurological and neuropsychiatric diseases including rare disorders. The company is rapidly progressing multiple compounds in clinical trials across three platforms they are calcitonin gene related peptide receptor antagonism, glutamate modulation and myeloperoxidase inhibition. The headquarters is in USA.

    Company Website
    BIOHAVEN PHARMACEUTICAL HOLDING COMPANY LTD.

  2. Agios Pharmaceuticals

    World Rank (Aug-2026)
    6,312
    Market Cap (Aug-2026)
    2.004 Billion USD
    World Rank (Jan-05-2024)
    7,260
    Market Cap (Jan-05-2024)
    1.340 Billion USD
    World Rank (Jul-30-2023)
    6,950
    Market Cap (Jul-30-2023)
    1.477 Billion USD
    World Rank (Dec-25-2022)
    6,594
    Market Cap (Dec-25-2022)
    1.485 Billion USD
    World Rank (Jan-07-2022)
    6,755
    Market Cap (Jan-07-2022)
    1.77 Billion USD
    Annual Revenue in USD
    54 Million USD
    Annual Operating Income in USD
    -472 Million USD
    Annual Net Income in USD
    -413 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    USA
    Yahoo @ Nasdaq
    Company Profile
    Bio-pharmaceutical company with headquarters is in Massachusetts, USA.
    Company Website
    AGIOS PHARMACEUTICALS INC

  3. Sarepta Therapeutics

    World Rank (Aug-2026)
    6,508
    Market Cap (Aug-2026)
    1.912 Billion USD
    World Rank (Jan-05-2024)
    1,838
    Market Cap (Jan-05-2024)
    8.820 Billion USD
    World Rank (Jul-30-2023)
    1,662
    Market Cap (Jul-30-2023)
    10.109 Billion USD
    World Rank (Dec-25-2022)
    1,373
    Market Cap (Dec-25-2022)
    11.407 Billion USD
    World Rank (Jan-07-2022)
    2,400
    Market Cap (Jan-07-2022)
    7.45 Billion USD
    Annual Revenue in USD
    1,864 Million USD
    Annual Operating Income in USD
    -700 Million USD
    Annual Net Income in USD
    -713 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    USA
    Yahoo @ Nasdaq
    Company Profile

    Biotechnology company with headquarters is in Massachusetts, USA.

    Company Website
    SAREPTA THERAPEUTICS INC
    Wikipedia
    Wikipedia

  4. Constellation Pharmaceuticals

    World Rank (Aug-2026)
    6,721
    World Rank (Jan-05-2024)
    6,721
    World Rank (Jul-30-2023)
    6,721
    World Rank (Dec-25-2022)
    6,721
    World Rank (Jan-07-2022)
    6,721
    Annual Operating Income in USD
    -125 Million USD
    Annual Net Income in USD
    -126 Million USD
    Annual Results for Period Ending
    For year ending December-2020
    Headquarters Country
    USA
    Company Profile
    Constellation Pharmaceuticals is a Clinical Stage Biopharmaceutical company. The company using expertise in epigenetics to discover and develop novel therapeutics that address serious unmet medical needs in patients with cancers associated with abnormal gene expression.
    Company Website
    CONSTELLATION PHARMACEUTICALS

  5. ANI Pharmaceuticals Inc.

    World Rank (Aug-2026)
    6,839
    Market Cap (Aug-2026)
    1.757 Billion USD
    World Rank (Jan-05-2024)
    7,914
    Market Cap (Jan-05-2024)
    1.149 Billion USD
    World Rank (Jul-30-2023)
    8,477
    Market Cap (Jul-30-2023)
    1.055 Billion USD
    World Rank (Dec-25-2022)
    10,448
    Market Cap (Dec-25-2022)
    0.689 Billion USD
    World Rank (Jan-07-2022)
    11,253
    Market Cap (Jan-07-2022)
    0.73 Billion USD
    Annual Revenue in USD
    883 Million USD
    Annual Operating Income in USD
    111 Million USD
    Annual Net Income in USD
    78 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    USA
    Yahoo @ Stuttgart
    Company Profile
    ANI Pharmaceuticals is an Integrated Specialty Pharmaceutical company. It is focused on delivering value to customers by developing, manufacturing and marketing high quality branded and generic prescription pharmaceuticals. The company annual revenue is 206.5 million USD and 338 employees as on 2019. The headquarters is in USA.
    Company Website
    ANI PHARMACEUTICALS INC

  6. Amphastar Pharmaceuticals

    World Rank (Aug-2026)
    9,798
    Market Cap (Aug-2026)
    0.889 Billion USD
    World Rank (Jan-05-2024)
    4,332
    Market Cap (Jan-05-2024)
    3.040 Billion USD
    World Rank (Jul-30-2023)
    4,422
    Market Cap (Jul-30-2023)
    2.937 Billion USD
    World Rank (Dec-25-2022)
    6,890
    Market Cap (Dec-25-2022)
    1.386 Billion USD
    World Rank (Jan-07-2022)
    8,516
    Market Cap (Jan-07-2022)
    1.20 Billion USD
    Annual Revenue in USD
    720 Million USD
    Annual Operating Income in USD
    140 Million USD
    Annual Net Income in USD
    98 Million USD
    Annual Results for Period Ending
    For year ending December-2025
    Headquarters Country
    USA
    Yahoo @ Nasdaq
    Company Profile
    Amphastar Pharmaceuticals is a Specialty Pharmaceutical company that is engaged in the development, manufacture and marketing of generic and proprietary injectable, intranasal and inhalation products. It produce over 20 commercial products while continue to develop a portfolio of generic and branded products that target large markets with high technical barriers to entry. The headquarters is in USA.
    Company Website
    Amphastar Pharmaceuticals

Share